问 题 推荐  收藏
提问:xwbwwj
级别:幼儿园
来自:湖南省邵阳市

悬赏分:0
回答数:1
浏览数:
已解决的问题 请英语老师高手翻译一下
In this scheme various methods are shown for the synthesis of (S)-atenolol: 1. Treatment of (R)-glycidyl 4-nitrobenzenesulfonate (I) with HCl (either concentrated or with dichloromethane) provides 3-chloropropyl derivative (II), which is then coupled with isopropylamine (III) in dichloromethane to afford 3-chloropropylisopropylamine (IV). Finally, condensation of (IV) with 2-(4-hydroxyphenyl)acetamide (V) by means of KOH in MeOH gives the desired product. Alternatively, derivative (IV) can be converted into (S)-atenolol by its condensation with 2-(4-hydroxy-phenyl)acetonitrile (VI) by means of KOH to yield compound (VII), followed by hydrolysis with HCl at 40 C. 2. Condensation of (R)-glycidyl 3-nitrobenzenesulfonate (VIII) with isopropylamine (III) followed by coupling with acetamide (V) by means of potassium tert-butylate in DMSO provides the desired product. 3. Treatment of (VIII) with HCl affords 2(S)-hydroxy-3-chloropropyl-3-nitrobenzenesulfonate (IX), which is first coupled with isopropylamine (III) to give (IV) and finally condensed with amide (V).
 提问时间:2008-01-08 10:02:36    评论2举报
最佳答案此答案已被选择为最佳答案,但并不代表问吧支持或赞同其观点
回答:少女时代
级别:硕士研究生

2008-01-08 12:53:18
来自:贵州省贵阳市
在这项计划的各种方法,是次展览为合成( S ) -氨酰心安: 1 。治疗( R )的甘油酯4 - nitrobenzenesulfonate (一)与盐酸(无论是集中或二氯甲烷)提供3 -氯丙基衍生物(二) ,然后再加上异丙胺(三)在二氯甲烷负担3 - chloropropylisopropylamine (四) 。最后,凝结(四) 2 -( 4 -羟苯基)乙酰胺(五)的方式在氢氧化钾甲醇给人的理想产品。另外,衍生金融工具(四) ,可以换算成( ) -氨酰心安,由它凝结2 -( 4 -羟苯基)乙腈(六)的方式,以氢氧化钾产量化合物(七) ,其次是水解用H Cl4 0长2 。凝结( R )的甘油酯3 - nitrobenzenesulfonate (八)与异丙胺(三) ,其次为配合乙酰胺(五)的方式钾叔丁酯在DMSO提供了理想的产品。 3 。治疗(八)用HCl给予2 ( ) -羟基-3 -氯丙基- 3 - nitrobenzenesulfonate (九) ,这是第一次,再加上异丙胺(三) ,使(四) ,最后浓缩与酰胺(五)

网上翻译的 怎么像是化学?
揪错评论举报
提问者对答案的评价:
非常感谢!你真棒!
总回答数1,每页15条,当前第1页,共1页